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Janux Therapeutics reports deep B-cell depletion in Phase 1 trial of JANX011

By Public Technologies
  • Janux Therapeutics announced initial Phase 1 results for JANX011 in 25 healthy volunteers, supporting planned development in autoimmune diseases.
  • A single injection produced deep, sustained B-cell depletion without step-up dosing, with selective activation of the intended T-cell subset.
  • No serious adverse events occurred; cytokine release syndrome was mild, while transient, asymptomatic liver enzyme elevations required no treatment.
  • Patient trials target immune thrombocytopenia in first-half 2027, followed by rheumatoid arthritis in the second half.


Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Janux Therapeutics Inc. published the original content used to generate this news brief via Business Wire (Ref. ID: 20261109651964) on November 09, 2026, and is solely responsible for the information contained therein.

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