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BioNTech, DualityBio Breast Cancer Drug Shows Modest Progression-Free Survival Gain in Phase 3 Trial

By Public Technologies
  • BioNTech and DualityBio announced topline results from the Phase 3 DYNASTY-Breast02 breast cancer trial on October 26, 2026.
  • Trastuzumab pamirtecan modestly delayed disease progression versus chemotherapy in chemotherapy-naive patients with HR+/HER2-low metastatic breast cancer whose disease progressed on endocrine therapy.
  • Overall survival data were not mature at the interim analysis.
  • Interstitial lung disease occurred more frequently than in prior trials, mostly as mild or moderate cases; some cases were severe or fatal.
  • The partners see limited potential patient benefit in the current treatment landscape and will review the data to determine next steps.


Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. BioNTech SE published the original content used to generate this news brief via GlobeNewswire (Ref. ID: 202610260500PRIMZONEFULLFEED1001279831) on October 26, 2026, and is solely responsible for the information contained therein.

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