Merck says tulisokibart hits primary endpoint in Phase 2b hidradenitis suppurativa trial

• Merck disclosed first Phase 2b results for tulisokibart in moderate-to-severe hidradenitis suppurativa, slated for presentation at EADV 2026.
• The trial met the main efficacy goal, showing patients on higher-dose regimens were more likely to improve than on placebo.
• Key secondary measures also trended in favor of treatment, including deeper clinical responses and better patient-reported quality of life.
• Safety looked broadly comparable with placebo, with serious adverse events uncommon and no serious or opportunistic infections reported.
• Merck plans to move the drug into Phase 3 in hidradenitis suppurativa, expanding its anti-TL1A program beyond inflammatory bowel disease.

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