Grail Publishes Presentation on Blood-Based Detection of Liver and Bile Duct Cancers

By Public Technologies
  • Grail published a medical research presentation evaluating targeted ctDNA methylation profiling for liver and biliary tract cancers.
  • The blood test detected cancer signals in 86-95% of samples from 657 patients across three phase 3 trials.
  • A research-grade classifier identified 99.2% of biliary tract cancers as adenocarcinoma-like; HCC classification accuracy reached 77.4-81.9%.
  • Confirmed HCC samples classified as adenocarcinoma-like had lower tumor methylation fractions, highlighting a need for further classifier refinement and validation.


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