Gilead’s Livdelzi meets ALP normalization endpoint in 75.4% of patients in Phase 3 PBC trial
- Gilead Sciences reported Phase 3 IDEAL results showing Livdelzi normalized a key liver disease marker more often than placebo in primary biliary cholangitis.
- The trial evaluated second-line treatment in patients with mildly elevated alkaline phosphatase levels, a population largely excluded from previous pivotal trials.
- No new safety concerns emerged; adverse event rates were generally similar between treatment groups.
- Gilead is discussing the results with global regulators.
- Results will be presented at The Liver Meeting in Denver, November 5-9, 2026; publication has been accepted by the Journal of Hepatology.
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