Bristol Myers Squibb’s Zola-Cel Shows Early Efficacy in Phase 1 Multiple Sclerosis Trial

• Bristol Myers Squibb is presenting interim Phase 1 Breakfree-2 results for investigational multiple sclerosis therapy zola-cel today at MSToronto 2026.
• Early findings showed potential to control relapses and stabilize disability in patients with highly active relapsing or progressive disease.
• All patients receiving the higher dose remained off disease-modifying therapies at last follow-up, including some followed for more than a year.
• Most adverse events were brief and reversible; one severe neurological event resolved with treatment.
• Following the data cutoff, one patient died from septic pneumonia following high-dose cyclophosphamide treatment for unresolved motor symptoms.

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