BridgeBio Publishes Presentation on Encaleret Phase 3 CALIBRATE Results

By Public Technologies14:41 (UTC), 26 October 2026 Updated

BridgeBio Pharma published a medical research presentation detailing 24-week results from the phase 3 CALIBRATE trial of encaleret in autosomal dominant hypocalcemia type 1.
The composite serum and urinary calcium endpoint was achieved by 76% of encaleret recipients versus 19% receiving standard care (p<0.0001).
Mean eGFR increased by 11 mL/min/1.73 m² with encaleret versus 3 mL/min/1.73 m² with standard care.
Serious treatment-emergent adverse events occurred in 9% of encaleret recipients versus 14% receiving standard care.
No treatment-emergent adverse events led to encaleret discontinuation during randomized treatment.

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