AstraZeneca's Tezspire improves eosinophilic esophagitis symptoms in Phase III trial

• AstraZeneca and Amgen’s Tezspire met the Phase III CROSSING trial’s main goals in eosinophilic esophagitis, improving swallowing symptoms and tissue inflammation versus placebo.
• Benefits persisted through one year; treatment also cleared visible signs of disease in some patients.
• Results were presented at United European Gastroenterology Week 2026 in Barcelona, Spain.
• The safety profile was consistent with existing indications.
• AstraZeneca plans to share the findings with regulators to pursue Tezspire’s use in eosinophilic esophagitis.

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