Novo Nordisk's CagriSema shows 25.4% mean weight loss in early responders in post hoc analysis

By Public Technologies
  • Novo Nordisk announced post hoc REDEFINE 1 analyses showing greater weight loss among early responders to investigational obesity treatment CagriSema.
  • Patients receiving CagriSema reported meaningful improvements in physical and psychosocial function more often than those receiving placebo.
  • Results were presented at ObesityWeek 2026; the early-response findings are hypothesis-generating, not a basis for changing clinical decisions.
  • Gastrointestinal side effects predominated; treatment discontinuations due to adverse events were more common with CagriSema than placebo.
  • A US regulatory decision on CagriSema for weight management is expected in the fourth quarter of 2026 following its December 2025 application.


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