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Arvinas presents preclinical data on BCL6 degrader ARV-393 in lymphoma

By Public Technologies
  • Arvinas’ VEPPANU (vepdegestrant) received FDA approval on May 1, 2026, becoming the first approved PROTAC protein degrader.
  • Rigel licensed VEPPANU in May 2026; commercial availability began in August 2026, with potential milestone payments and tiered royalties.
  • Cash runway extends into the second half of 2028; clinical-stage partnerships with Pfizer and Novartis generated more than $800 million.
  • Novartis is evaluating luxdegalutamide in three Phase 2 combination trials under a licensing deal potentially worth more than $1 billion.
  • ARV-393’s Phase 1 trial is enrolling lymphoma patients for monotherapy treatment or combination treatment with glofitamab.


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