CRISPR Therapeutics' CTX310 lowers triglycerides 63% in Phase 1b trial

By Public Technologies
  • CRISPR Therapeutics presented Phase 1b results for CTX310 in severe hypertriglyceridemia today at the American Heart Association Scientific Sessions 2026.
  • The investigational gene-editing therapy substantially reduced triglycerides following a single treatment, with reductions maintained during longer follow-up.
  • Treatment was well tolerated, with no treatment-related serious adverse events or clinically relevant liver enzyme elevations.
  • The FDA recently granted CTX310 Regenerative Medicine Advanced Therapy designations for severe hypertriglyceridemia and elevated LDL cholesterol; Phase 1b trials remain ongoing.


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