Merck, Moderna therapy cuts melanoma recurrence or death risk 42% in Phase 3 trial

By Public Technologies
  • Merck and Moderna reported positive Phase 3 INTerpath-001 results for investigational intismeran autogene combined with Keytruda in completely resected stage IIB-IV melanoma.
  • The combination significantly reduced recurrence or death and distant metastasis or death compared with Keytruda alone.
  • Results will be presented for the first time at the ESMO Congress 2026 Presidential Symposium.
  • No new safety signals emerged; overall survival data remain immature, with a favorable trend observed.
  • The partners are engaging with regulatory authorities based on the findings.


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