Immutep's IMP761 Shows Significant Suppression of T-Cell Immune Responses in Phase I Trial
- Immutep announced positive Phase I results for IMP761 in healthy volunteers, presented at ACR Convergence 2026.
- A single infusion significantly suppressed T-cell-driven immune responses, with stronger effects at higher drug exposure.
- IMP761 was well tolerated across all seven dose levels, with no serious or severe adverse events reported.
- The ongoing multiple-dose phase has shown no new safety signals; the drug's pharmacokinetic profile supports dosing every four weeks.
- Results from the multiple-dose phase are expected in the first half of 2027 to guide dose selection for a potential Phase II program.
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