Boston Scientific's WATCHMAN FLX Pro trial meets primary endpoints

By Public Technologies
  • Boston Scientific reported positive six-month primary results from the SIMPLAAFY trial of its WATCHMAN FLX Pro left atrial appendage closure device.
  • Aspirin alone and reduced-dose anticoagulant regimens matched dual antiplatelet therapy for stroke protection, with less bleeding, supporting simpler post-implant treatment.
  • The reduced-dose anticoagulant regimen also showed fewer device-related blood clots than dual antiplatelet therapy.
  • Results were presented at Transcatheter Cardiovascular Therapeutics 2026 and simultaneously published in JAMA.


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