Cabaletta Bio's Rese-cel Shows Sustained One-Year Responses in All Six Dermatomyositis Patients

By Public Technologies
  • Cabaletta Bio announced new Phase 1/2 rese-cel results for presentation at ACR Convergence 2026 on November 8-9.
  • Dermatomyositis patients maintained improvement without immunomodulators through one year; lupus nephritis patients achieved remission with biopsy evidence of reduced disease activity.
  • Systemic sclerosis patients showed sustained improvement without immunomodulators through one year, including better lung function among those with interstitial lung disease.
  • Safety findings across 71 patients supported a favorable benefit-risk profile, with mostly mild or no cytokine release syndrome.
  • Registrational dermatomyositis trial results are expected in the second half of 2027, with a myositis biologics application planned for first-quarter 2028.


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